Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Col2a1  collagen, type II, alpha 1   (Synonyms: Col2, Col2a, Col2a-1, Del1, Lpk, M100413, M100856, Rgsc413, Rgsc856)
Results	Reference
1	J:202628 Bedore J, Sha W, McCann MR, Liu S, Leask A, Seguin CA, Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. Arthritis Rheum. 2013 Oct;65(10):2634-44
1	J:273150 Bell PA, Dennis EP, Hartley CL, Jackson RM, Porter A, Boot-Handford RP, Pirog KA, Briggs MD, Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis. Cell Stress Chaperones. 2019 Jan;24(1):159-173
1	J:96524 Bengtsson T, Aszodi A, Nicolae C, Hunziker EB, Lundgren-Akerlund E, Fassler R, Loss of {alpha}10{beta}1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci. 2005 Mar 1;118(Pt 5):929-36
1	J:78596 Brandau O, Aszodi A, Hunziker EB, Neame PJ, Vestweber D, Fassler R, Chondromodulin I is dispensable during enchondral ossification and eye development. Mol Cell Biol. 2002 Sep;22(18):6627-35
1	J:310741 Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML, Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 2014 Dec 22;31(6):707-21
1*	J:231358 Cameron TL, Gresshoff IL, Bell KM, Pirog KA, Sampurno L, Hartley CL, Sanford EM, Wilson R, Ermann J, Boot-Handford RP, Glimcher LH, Briggs MD, Bateman JF, Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization. Osteoarthritis Cartilage. 2015 Apr;23(4):661-70
1	J:228212 Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C, FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5
1	J:345073 Eley L, Richardson RV, Alqahtani A, Chaudhry B, Henderson DJ, eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling. Dis Model Mech. 2024 Jan 1;17(1)
1	J:202337 Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM, Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol. 2013 Oct 15;382(2):375-84
1*	J:18628 Fassler R, Schnegelsberg PN, Dausman J, Shinya T, Muragaki Y, McCarthy MT, Olsen BR, Jaenisch R, Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5070-4
1	J:264602 Gamer LW, Pregizer S, Gamer J, Feigenson M, Ionescu A, Li Q, Han L, Rosen V, The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint. J Bone Miner Res. 2018 Sep;33(9):1708-1717
1	J:257361 Gamer LW, Xiang L, Rosen V, Formation and maturation of the murine meniscus. J Orthop Res. 2017 Aug;35(8):1683-1689
1	J:110783 Grashoff C, Aszodi A, Sakai T, Hunziker EB, Fassler R, Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep. 2003 Apr;4(4):432-8
1	J:223502 Hata K, Takashima R, Amano K, Ono K, Nakanishi M, Yoshida M, Wakabayashi M, Matsuda A, Maeda Y, Suzuki Y, Sugano S, Whitson RH, Nishimura R, Yoneda T, Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes. Nat Commun. 2013;4:2850
1*	J:174146 Heinonen J, Taipaleenmaki H, Roering P, Takatalo M, Harkness L, Sandholm J, Uusitalo-Jarvinen H, Kassem M, Kiviranta I, Laitala-Leinonen T, Saamanen AM, Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes. Osteoarthritis Cartilage. 2011 Aug;19(8):1026-35
1	J:250431 Heinonen J, Zhang FP, Surmann-Schmitt C, Honkala S, Stock M, Poutanen M, Saamanen AM, Defects in chondrocyte maturation and secondary ossification in mouse knee joint epiphyses due to Snorc deficiency. Osteoarthritis Cartilage. 2017 Jul;25(7):1132-1142
1	J:215404 Hering TM, Wirthlin L, Ravindran S, McAlinden A, Changes in type II procollagen isoform expression during chondrogenesis by disruption of an alternative 5' splice site within Col2a1 exon 2. Matrix Biol. 2014 Jun;36:51-63
1	J:213598 Hu J, Lu J, Lian G, Ferland RJ, Dettenhofer M, Sheen VL, Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Hum Mol Genet. 2014 Sep 1;23(17):4663-73
1	J:213355 Hu J, Lu J, Lian G, Zhang J, Hecht JL, Sheen VL, Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS One. 2014;9(2):e89352
1	J:280264 Hubmacher D, Taye N, Balic Z, Thacker S, Adams SM, Birk DE, Schweitzer R, Apte SS, Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia. Matrix Biol. 2019 Sep;82:38-53
1	J:269621 Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K, Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1. Sci Rep. 2018 Nov 20;8(1):17134
1	J:81856 Ihanamaki T, Saamanen AM, Suominen J, Pelliniemi LJ, Harley V, Vuorio E, Salminen H, Expression of Sox9 and type IIA procollagen during ocular development and aging in transgenic Del1 mice with a mutation in the type II collagen gene. Eur J Ophthalmol. 2002 Nov-Dec;12(6):450-8
1	J:80671 Ihanamaki T, Salminen H, Saamanen AM, Sandberg-Lall M, Vuorio E, Pelliniemi LJ, Ultrastructural characterization of developmental and degenerative vitreo-retinal changes in the eyes of transgenic mice with a deletion mutation in type II collagen gene. Curr Eye Res. 2002 Jun;24(6):439-50
1	J:83260 Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM, Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003 Jun;130(12):2779-91
1	J:241397 Kamper M, Paulsson M, Zaucke F, Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop. Cell Tissue Res. 2017 Feb;367(2):359-367
1	J:87676 Ko Y, Kobbe B, Nicolae C, Miosge N, Paulsson M, Wagener R, Aszodi A, Matrilin-3 is dispensable for mouse skeletal growth and development. Mol Cell Biol. 2004 Feb;24(4):1691-9
1	J:266580 Kobayashi T, Kozlova A, Lin28a overexpression reveals the role of Erk signaling in articular cartilage development. Development. 2018 Aug 2;145(15):dev162594
1	J:202964 Lai LP, Lilley BN, Sanes JR, McMahon AP, Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19450-5
1	J:204893 Lawson KA, Teteak CJ, Zou J, Hacquebord J, Ghatan A, Zielinska-Kwiatkowska A, Fernandes RJ, Chansky HA, Yang L, Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes. J Biol Chem. 2013 Nov 8;288(45):32119-25
1	J:184499 Lewis R, Ravindran S, Wirthlin L, Traeger G, Fernandes RJ, McAlinden A, Disruption of the developmentally-regulated Col2a1 pre-mRNA alternative splicing switch in a transgenic knock-in mouse model. Matrix Biol. 2012 Apr;31(3):214-26
1	J:317557 Li X, Liu H, Gu S, Liu C, Sun C, Zheng Y, Chen Y, Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice. Cell Tissue Res. 2014 Feb;355(2):345-54
1*	J:90275 Lincoln J, Alfieri CM, Yutzey KE, Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn. 2004 Jun;230(2):239-50
1	J:182166 Liu CF, Aschbacher-Smith L, Barthelery NJ, Dyment N, Butler D, Wylie C, Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon. Tissue Eng Part A. 2012 Mar;18(5-6):598-608
1	J:342646 Liu H, Li P, Zhang S, Xiang J, Yang R, Liu J, Shafiquzzaman M, Biswas S, Wei Z, Zhang Z, Zhou X, Yin F, Xie Y, Goff SP, Chen L, Li B, Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice. Nat Genet. 2022 Dec;54(12):1946-1958
1	J:87618 Maes C, Stockmans I, Moermans K, Van Looveren R, Smets N, Carmeliet P, Bouillon R, Carmeliet G, Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest. 2004 Jan;113(2):188-99
1	J:134987 Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y, Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development. 2008 Jun;135(11):1947-56
1*	J:289776 Mao G, Kang Y, Lin R, Hu S, Zhang Z, Li H, Liao W, Zhang Z, Long Non-coding RNA HOTTIP Promotes CCL3 Expression and Induces Cartilage Degradation by Sponging miR-455-3p. Front Cell Dev Biol. 2019;7:161
1	J:246045 Marulanda J, Eimar H, McKee MD, Berkvens M, Nelea V, Roman H, Borras T, Tamimi F, Ferron M, Murshed M, Matrix Gla protein deficiency impairs nasal septum growth, causing midface hypoplasia. J Biol Chem. 2017 Jul 07;292(27):11400-11412
1	J:152912 Matsumoto K, Li Y, Jakuba C, Sugiyama Y, Sayo T, Okuno M, Dealy CN, Toole BP, Takeda J, Yamaguchi Y, Kosher RA, Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Development. 2009 Aug;136(16):2825-35
1*	J:98500 Meech R, Edelman DB, Jones FS, Makarenkova HP, The homeobox transcription factor Barx2 regulates chondrogenesis during limb development. Development. 2005 May;132(9):2135-46
1	J:160358 Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz MK, Ueno-Kudo H, Asahara H, MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010 Jun 1;24(11):1173-85
1	J:327295 Mohamed FF, Ge C, Cowling RT, Lucas D, Hallett SA, Ono N, Binrayes AA, Greenberg B, Franceschi RT, The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development. Bone Res. 2022 Feb 9;10(1):11
1	J:334575 Mohamed FF, Ge C, Hallett SA, Bancroft AC, Cowling RT, Ono N, Binrayes AA, Greenberg B, Levi B, Kaartinen VM, Franceschi RT, Control of craniofacial development by the collagen receptor, discoidin domain receptor 2. Elife. 2023 Jan 19;12
1*	J:74659 Moser M, Bosserhoff AK, Hunziker EB, Sandell L, Fassler R, Buettner R, Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice. Mol Cell Biol. 2002 Mar;22(5):1438-45
1	J:295274 Oichi T, Taniguchi Y, Soma K, Oshima Y, Yano F, Mori Y, Chijimatsu R, Kim-Kaneyama JR, Tanaka S, Saito T, Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway. Cell Mol Life Sci. 2019 Dec;76(23):4795-4809
1*	J:306318 Ono K, Hata K, Nakamura E, Ishihara S, Kobayashi S, Nakanishi M, Yoshida M, Takahata Y, Murakami T, Takenoshita S, Komori T, Nishimura R, Yoneda T, Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2. Commun Biol. 2021 Mar 11;4(1):326
1	J:100747 Ortega N, Behonick DJ, Colnot C, Cooper DN, Werb Z, Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol Biol Cell. 2005 Jun;16(6):3028-39
1	J:258274 Patra D, DeLassus E, Mueller J, Abou-Ezzi G, Sandell LJ, Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. Biol Open. 2018 Feb 22;7(2):bio032094
1*	J:121268 Plumb DA, Dhir V, Mironov A, Ferrara L, Poulsom R, Kadler KE, Thornton DJ, Briggs MD, Boot-Handford RP, Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens. J Biol Chem. 2007 Apr 27;282(17):12791-5
1	J:182341 Plumb DA, Ferrara L, Torbica T, Knowles L, Mironov A Jr, Kadler KE, Briggs MD, Boot-Handford RP, Collagen XXVII organises the pericellular matrix in the growth plate. PLoS One. 2011;6(12):e29422
1	J:340421 Ruscitto A, Chen P, Tosa I, Wang Z, Zhou G, Safina I, Wei R, Morel MM, Koch A, Forman M, Reeve G, Lecholop MK, Wilson M, Bonthius D, Chen M, Ono M, Wang TC, Yao H, Embree MC, Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity. Cell Stem Cell. 2023 Sep 7;30(9):1179-1198.e7
1	J:161526 Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H, Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med. 2010 Jun;16(6):678-86
1	J:72709 Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS, Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 2001 Nov 1;15(21):2865-76
1	J:245905 Spieker J, Mudersbach T, Vogel-Hopker A, Layer PG, Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures. PLoS One. 2017;12(1):e0170252
1	J:206807 Staal B, Williams BO, Beier F, Vande Woude GF, Zhang YW, Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2590-5
1	J:309484 Tessier S, Doolittle AC, Sao K, Rotty JD, Bear JE, Ulici V, Loeser RF, Shapiro IM, Diekman BO, Risbud MV, Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. JCI Insight. 2020 Feb 27;5(4)
1	J:199887 Tomita N, Hattori T, Itoh S, Aoyama E, Yao M, Yamashiro T, Takigawa M, Cartilage-specific over-expression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth. PLoS One. 2013;8(3):e59226
1*	J:154906 Wang W, Lian N, Li L, Moss HE, Wang W, Perrien DS, Elefteriou F, Yang X, Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development. 2009 Dec;136(24):4143-53
1	J:101174 Wang Y, Xiao R, Yang F, Karim BO, Iacovelli AJ, Cai J, Lerner CP, Richtsmeier JT, Leszl JM, Hill CA, Yu K, Ornitz DM, Elisseeff J, Huso DL, Jabs EW, Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development. 2005 Aug;132(15):3537-48
1*	J:166870 Watanabe Y, Takeuchi K, Higa Onaga S, Sato M, Tsujita M, Abe M, Natsume R, Li M, Furuichi T, Saeki M, Izumikawa T, Hasegawa A, Yokoyama M, Ikegawa S, Sakimura K, Amizuka N, Kitagawa H, Igarashi M, Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J. 2010 Oct 25;432(1):47-55
1	J:281388 Xu J, Huang Z, Wang W, Tan X, Li H, Zhang Y, Tian W, Hu T, Chen YP, FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate. J Dent Res. 2018 May;97(5):589-596
1	J:97410 Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM, Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5062-7
1	J:221866 Yoshida M, Hata K, Takashima R, Ono K, Nakamura E, Takahata Y, Murakami T, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T, The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun. 2015;6:6653
1	J:274387 Yoshimoto Y, Takimoto A, Watanabe H, Hiraki Y, Kondoh G, Shukunami C, Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system. Sci Rep. 2017 Mar 22;7:45010
1*	J:316481 Yu D, Hu J, Sheng Z, Fu G, Wang Y, Chen Y, Pan Z, Zhang X, Wu Y, Sun H, Dai J, Lu L, Ouyang H, Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFbeta signaling. Osteoarthritis Cartilage. 2020 Jan;28(1):112-121
1	J:241416 Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ, CCN1 Regulates Chondrocyte Maturation and Cartilage Development. J Bone Miner Res. 2016 Mar;31(3):549-59
1	J:244380 Zieba J, Forlenza KN, Khatra JS, Sarukhanov A, Duran I, Rigueur D, Lyons KM, Cohn DH, Merrill AE, Krakow D, TGFbeta and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions. PLoS Genet. 2016 Mar;12(3):e1005936